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SIRT1 inhibition promotes atherosclerosis through impaired autophagy

SIRT1, a highly conserved NAD(+)-dependent protein deacetylase, plays a pivotal role in the pathogenesis and therapy of atherosclerosis (AS). The aim of this study is to investigate the potential effects of SIRT1 on AS in ApoE(–/–) mice and the underlying mechanisms of autophagy in an ox-LDL-stimula...

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Detalles Bibliográficos
Autores principales:	Yang, Xiaofeng, Wei, Jingyuan, He, Yanhao, Jing, Ting, Li, Yanxiang, Xiao, Yunfang, Wang, Bo, Wang, Weirong, Zhang, Jiye, Lin, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584260/ https://www.ncbi.nlm.nih.gov/pubmed/28881659 http://dx.doi.org/10.18632/oncotarget.17691

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