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G-CSF inhibits LFA-1-mediated CD4(+) T cell functions by inhibiting Lck and ZAP-70

In this study, we showed that G-CSF mobilization increased the frequency of T cells, specifically CD3(+)CD4(+) T cells. G-CSF mobilization decreased the secretion of inflammatory cytokines of CD4(+) T cells through the LFA-1/ICAM-1 signaling pathway, whereas it did not alter the TH1/TH2 ratio. We fo...

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Detalles Bibliográficos
Autores principales:	Zhao, Shasha, Gu, Zhenyang, Wang, Li, Guan, Lixun, Wang, Feiyan, Yang, Nan, Luo, Lan, Gao, Zhe, Song, Yingwei, Wang, Lili, Liu, Daihong, Gao, Chunji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584271/ https://www.ncbi.nlm.nih.gov/pubmed/28881670 http://dx.doi.org/10.18632/oncotarget.18194

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