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Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study

BACKGROUND: Esophageal cancer carries a poor prognosis with an overall 5-year survival of less than 20%. However, the causes of death in patients with esophageal cancer have not been well described. METHODS: This nationwide, population-based cohort study included 18 229 esophageal cancer patients wh...

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Autores principales: Xie, Shao-Hua, Wahlin, Karl, Lagergren, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584290/
https://www.ncbi.nlm.nih.gov/pubmed/28881689
http://dx.doi.org/10.18632/oncotarget.15270
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author Xie, Shao-Hua
Wahlin, Karl
Lagergren, Jesper
author_facet Xie, Shao-Hua
Wahlin, Karl
Lagergren, Jesper
author_sort Xie, Shao-Hua
collection PubMed
description BACKGROUND: Esophageal cancer carries a poor prognosis with an overall 5-year survival of less than 20%. However, the causes of death in patients with esophageal cancer have not been well described. METHODS: This nationwide, population-based cohort study included 18 229 esophageal cancer patients who were diagnosed between 1961 and 2014 in Sweden. We assessed the distribution of main causes of death in patients with esophageal cancer and used competing-risks regression to compare the cause-specific risks of death across sexes, ages at diagnosis, and calendar periods of diagnosis. RESULTS: A total of 16 938 (92.9%) patients died during follow-up. Esophageal cancer accounted for 79.5% of all reported deaths. Other major causes of death were non-esophageal cancers (9.8%), ischemic heart disease or cerebrovascular disease (4.2%) and respiratory diseases (1.3%). Female patients had a lower risk of death from esophageal cancer (sub-hazard ratio [SHR]=0.90, 95% confidence interval [CI]: 0.87, 0.94), which was more pronounced in patients with squamous cell carcinoma (SHR=0.85, 95% CI: 0.81, 0.89). Risks of death from esophageal cancer and other cancers in patients who were diagnosed in more recent calendar periods were lower than in those diagnosed in earlier periods. CONCLUSIONS: Patients diagnosed with esophageal cancer are more likely to die from this cancer than from other causes. However, these patients also face considerable risk of death from other cancers, ischemic heart disease, cerebrovascular disease, and respiratory diseases. These common causes of death should be taken into consideration in esophageal cancer management.
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spelling pubmed-55842902017-09-06 Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study Xie, Shao-Hua Wahlin, Karl Lagergren, Jesper Oncotarget Clinical Research Paper BACKGROUND: Esophageal cancer carries a poor prognosis with an overall 5-year survival of less than 20%. However, the causes of death in patients with esophageal cancer have not been well described. METHODS: This nationwide, population-based cohort study included 18 229 esophageal cancer patients who were diagnosed between 1961 and 2014 in Sweden. We assessed the distribution of main causes of death in patients with esophageal cancer and used competing-risks regression to compare the cause-specific risks of death across sexes, ages at diagnosis, and calendar periods of diagnosis. RESULTS: A total of 16 938 (92.9%) patients died during follow-up. Esophageal cancer accounted for 79.5% of all reported deaths. Other major causes of death were non-esophageal cancers (9.8%), ischemic heart disease or cerebrovascular disease (4.2%) and respiratory diseases (1.3%). Female patients had a lower risk of death from esophageal cancer (sub-hazard ratio [SHR]=0.90, 95% confidence interval [CI]: 0.87, 0.94), which was more pronounced in patients with squamous cell carcinoma (SHR=0.85, 95% CI: 0.81, 0.89). Risks of death from esophageal cancer and other cancers in patients who were diagnosed in more recent calendar periods were lower than in those diagnosed in earlier periods. CONCLUSIONS: Patients diagnosed with esophageal cancer are more likely to die from this cancer than from other causes. However, these patients also face considerable risk of death from other cancers, ischemic heart disease, cerebrovascular disease, and respiratory diseases. These common causes of death should be taken into consideration in esophageal cancer management. Impact Journals LLC 2017-02-11 /pmc/articles/PMC5584290/ /pubmed/28881689 http://dx.doi.org/10.18632/oncotarget.15270 Text en Copyright: © 2017 Xie et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Xie, Shao-Hua
Wahlin, Karl
Lagergren, Jesper
Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study
title Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study
title_full Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study
title_fullStr Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study
title_full_unstemmed Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study
title_short Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study
title_sort cause of death in patients diagnosed with esophageal cancer in sweden: a population-based study
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584290/
https://www.ncbi.nlm.nih.gov/pubmed/28881689
http://dx.doi.org/10.18632/oncotarget.15270
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