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Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease
Kawasaki disease (KD) is a form of systemic vasculitis. Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function. In this study, we recruited a total of 381 KD patients for genotyping. Data from 997 subjects (500 subjects from cohort 1;...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584296/ https://www.ncbi.nlm.nih.gov/pubmed/28881695 http://dx.doi.org/10.18632/oncotarget.17700 |
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author | Huang, Ying-Hsien Yang, Kuender D. Hsu, Yu-Wen Lu, Hsing-Fang Wong, Henry Sung-Ching Yu, Hong-Ren Kuo, Hsing-Chun Huang, Fu-Chen Lo, Mao-Hung Hsieh, Kai-Sheng Chen, Su-Fen Chang, Wei-Chiao Kuo, Ho-Chang |
author_facet | Huang, Ying-Hsien Yang, Kuender D. Hsu, Yu-Wen Lu, Hsing-Fang Wong, Henry Sung-Ching Yu, Hong-Ren Kuo, Hsing-Chun Huang, Fu-Chen Lo, Mao-Hung Hsieh, Kai-Sheng Chen, Su-Fen Chang, Wei-Chiao Kuo, Ho-Chang |
author_sort | Huang, Ying-Hsien |
collection | PubMed |
description | Kawasaki disease (KD) is a form of systemic vasculitis. Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function. In this study, we recruited a total of 381 KD patients for genotyping. Data from 997 subjects (500 subjects from cohort 1; 497 subjects from cohort 2) were used for analysis. Using TaqMan allelic discrimination, we determined five tag SNPs (rs916145, rs10421768, rs3817623, rs7251432, and rs2293689). Treatment outcome data related to such clinical phenotypes as coronary artery lesions (CAL), coronary artery aneurysms (CAA), and intravenous immunoglobulin (IVIG) effects were also collected. Furthermore, we measured plasma hepcidin levels with an enzyme-linked immunosorbent assay. We found that HAMP gene polymorphism (rs7251432, and rs2293689) was significantly correlated with KD risk and that plasma hepcidin levels both before and after IVIG treatment had a significantly positive correlation with length of hospital stays (R = 0.217, p = 0.046 and R = 0.381, p < 0.0001, respectively). In contrast, plasma hepcidin levels has a negative correlation with KD patients’ albumin levels (R = −0.27, p < 0.001) prior to IVIG treatment. This study's findings indicate that HAMP might have a role in the disease susceptibility, as well as its expressions correlated length of hospital stays, and albumin levels in Taiwanese children with KD. |
format | Online Article Text |
id | pubmed-5584296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55842962017-09-06 Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease Huang, Ying-Hsien Yang, Kuender D. Hsu, Yu-Wen Lu, Hsing-Fang Wong, Henry Sung-Ching Yu, Hong-Ren Kuo, Hsing-Chun Huang, Fu-Chen Lo, Mao-Hung Hsieh, Kai-Sheng Chen, Su-Fen Chang, Wei-Chiao Kuo, Ho-Chang Oncotarget Clinical Research Paper Kawasaki disease (KD) is a form of systemic vasculitis. Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function. In this study, we recruited a total of 381 KD patients for genotyping. Data from 997 subjects (500 subjects from cohort 1; 497 subjects from cohort 2) were used for analysis. Using TaqMan allelic discrimination, we determined five tag SNPs (rs916145, rs10421768, rs3817623, rs7251432, and rs2293689). Treatment outcome data related to such clinical phenotypes as coronary artery lesions (CAL), coronary artery aneurysms (CAA), and intravenous immunoglobulin (IVIG) effects were also collected. Furthermore, we measured plasma hepcidin levels with an enzyme-linked immunosorbent assay. We found that HAMP gene polymorphism (rs7251432, and rs2293689) was significantly correlated with KD risk and that plasma hepcidin levels both before and after IVIG treatment had a significantly positive correlation with length of hospital stays (R = 0.217, p = 0.046 and R = 0.381, p < 0.0001, respectively). In contrast, plasma hepcidin levels has a negative correlation with KD patients’ albumin levels (R = −0.27, p < 0.001) prior to IVIG treatment. This study's findings indicate that HAMP might have a role in the disease susceptibility, as well as its expressions correlated length of hospital stays, and albumin levels in Taiwanese children with KD. Impact Journals LLC 2017-05-08 /pmc/articles/PMC5584296/ /pubmed/28881695 http://dx.doi.org/10.18632/oncotarget.17700 Text en Copyright: © 2017 Huang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Huang, Ying-Hsien Yang, Kuender D. Hsu, Yu-Wen Lu, Hsing-Fang Wong, Henry Sung-Ching Yu, Hong-Ren Kuo, Hsing-Chun Huang, Fu-Chen Lo, Mao-Hung Hsieh, Kai-Sheng Chen, Su-Fen Chang, Wei-Chiao Kuo, Ho-Chang Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease |
title | Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease |
title_full | Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease |
title_fullStr | Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease |
title_full_unstemmed | Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease |
title_short | Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease |
title_sort | correlation of hamp gene polymorphisms and expression with the susceptibility and length of hospital stays in taiwanese children with kawasaki disease |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584296/ https://www.ncbi.nlm.nih.gov/pubmed/28881695 http://dx.doi.org/10.18632/oncotarget.17700 |
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