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Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action,...

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Detalles Bibliográficos
Autores principales: Asaduzzaman Khan, Md., Tania, Mousumi, Fu, Shangyi, Fu, Junjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584300/
https://www.ncbi.nlm.nih.gov/pubmed/28881699
http://dx.doi.org/10.18632/oncotarget.17206
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author Asaduzzaman Khan, Md.
Tania, Mousumi
Fu, Shangyi
Fu, Junjiang
author_facet Asaduzzaman Khan, Md.
Tania, Mousumi
Fu, Shangyi
Fu, Junjiang
author_sort Asaduzzaman Khan, Md.
collection PubMed
description Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics.
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spelling pubmed-55843002017-09-06 Thymoquinone, as an anticancer molecule: from basic research to clinical investigation Asaduzzaman Khan, Md. Tania, Mousumi Fu, Shangyi Fu, Junjiang Oncotarget Review Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics. Impact Journals LLC 2017-04-18 /pmc/articles/PMC5584300/ /pubmed/28881699 http://dx.doi.org/10.18632/oncotarget.17206 Text en Copyright: © 2017 Asaduzzaman Khan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Asaduzzaman Khan, Md.
Tania, Mousumi
Fu, Shangyi
Fu, Junjiang
Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
title Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
title_full Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
title_fullStr Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
title_full_unstemmed Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
title_short Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
title_sort thymoquinone, as an anticancer molecule: from basic research to clinical investigation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584300/
https://www.ncbi.nlm.nih.gov/pubmed/28881699
http://dx.doi.org/10.18632/oncotarget.17206
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