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Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584300/ https://www.ncbi.nlm.nih.gov/pubmed/28881699 http://dx.doi.org/10.18632/oncotarget.17206 |
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author | Asaduzzaman Khan, Md. Tania, Mousumi Fu, Shangyi Fu, Junjiang |
author_facet | Asaduzzaman Khan, Md. Tania, Mousumi Fu, Shangyi Fu, Junjiang |
author_sort | Asaduzzaman Khan, Md. |
collection | PubMed |
description | Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics. |
format | Online Article Text |
id | pubmed-5584300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55843002017-09-06 Thymoquinone, as an anticancer molecule: from basic research to clinical investigation Asaduzzaman Khan, Md. Tania, Mousumi Fu, Shangyi Fu, Junjiang Oncotarget Review Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics. Impact Journals LLC 2017-04-18 /pmc/articles/PMC5584300/ /pubmed/28881699 http://dx.doi.org/10.18632/oncotarget.17206 Text en Copyright: © 2017 Asaduzzaman Khan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Asaduzzaman Khan, Md. Tania, Mousumi Fu, Shangyi Fu, Junjiang Thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
title | Thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
title_full | Thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
title_fullStr | Thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
title_full_unstemmed | Thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
title_short | Thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
title_sort | thymoquinone, as an anticancer molecule: from basic research to clinical investigation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584300/ https://www.ncbi.nlm.nih.gov/pubmed/28881699 http://dx.doi.org/10.18632/oncotarget.17206 |
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