PD1 signal transduction pathways in T cells

The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very...

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Autores principales: Arasanz, Hugo, Gato-Cañas, Maria, Zuazo, Miren, Ibañez-Vea, Maria, Breckpot, Karine, Kochan, Grazyna, Escors, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584302/
https://www.ncbi.nlm.nih.gov/pubmed/28881701
http://dx.doi.org/10.18632/oncotarget.17232
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author Arasanz, Hugo
Gato-Cañas, Maria
Zuazo, Miren
Ibañez-Vea, Maria
Breckpot, Karine
Kochan, Grazyna
Escors, David
author_facet Arasanz, Hugo
Gato-Cañas, Maria
Zuazo, Miren
Ibañez-Vea, Maria
Breckpot, Karine
Kochan, Grazyna
Escors, David
author_sort Arasanz, Hugo
collection PubMed
description The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on PD1-dependent intracellular signaling pathways, and the consequences of disrupting PD1 signal transduction.
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spelling pubmed-55843022017-09-06 PD1 signal transduction pathways in T cells Arasanz, Hugo Gato-Cañas, Maria Zuazo, Miren Ibañez-Vea, Maria Breckpot, Karine Kochan, Grazyna Escors, David Oncotarget Review The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on PD1-dependent intracellular signaling pathways, and the consequences of disrupting PD1 signal transduction. Impact Journals LLC 2017-04-19 /pmc/articles/PMC5584302/ /pubmed/28881701 http://dx.doi.org/10.18632/oncotarget.17232 Text en Copyright: © 2017 Arasanz et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Arasanz, Hugo
Gato-Cañas, Maria
Zuazo, Miren
Ibañez-Vea, Maria
Breckpot, Karine
Kochan, Grazyna
Escors, David
PD1 signal transduction pathways in T cells
title PD1 signal transduction pathways in T cells
title_full PD1 signal transduction pathways in T cells
title_fullStr PD1 signal transduction pathways in T cells
title_full_unstemmed PD1 signal transduction pathways in T cells
title_short PD1 signal transduction pathways in T cells
title_sort pd1 signal transduction pathways in t cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584302/
https://www.ncbi.nlm.nih.gov/pubmed/28881701
http://dx.doi.org/10.18632/oncotarget.17232
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