BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

BACKGROUND: Facioscapulohumeral dystrophy (FSHD) is a progressive muscle disease caused by mutations that lead to epigenetic derepression and inappropriate transcription of the double homeobox 4 (DUX4) gene in skeletal muscle. Drugs that enhance the repression of DUX4 and prevent its expression in s...

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Detalles Bibliográficos
Autores principales: Campbell, Amy E., Oliva, Jonathan, Yates, Matthew P., Zhong, Jun Wen, Shadle, Sean C., Snider, Lauren, Singh, Nikita, Tai, Shannon, Hiramuki, Yosuke, Tawil, Rabi, van der Maarel, Silvère M., Tapscott, Stephen J., Sverdrup, Francis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584331/
https://www.ncbi.nlm.nih.gov/pubmed/28870238
http://dx.doi.org/10.1186/s13395-017-0134-x

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