WNT signaling – lung cancer is no exception

Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the various effects of activation and inhibition of the WNT signaling pathways are summarized in...

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Autores principales: Rapp, Judit, Jaromi, Luca, Kvell, Krisztian, Miskei, Gyorgy, Pongracz, Judit E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584342/
https://www.ncbi.nlm.nih.gov/pubmed/28870231
http://dx.doi.org/10.1186/s12931-017-0650-6
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author Rapp, Judit
Jaromi, Luca
Kvell, Krisztian
Miskei, Gyorgy
Pongracz, Judit E.
author_facet Rapp, Judit
Jaromi, Luca
Kvell, Krisztian
Miskei, Gyorgy
Pongracz, Judit E.
author_sort Rapp, Judit
collection PubMed
description Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the various effects of activation and inhibition of the WNT signaling pathways are summarized in the context of lung carcinogenesis. Recent evidence regarding WNT ligand transport mechanisms, the role of WNT signaling in lung cancer angiogenesis and drug transporter regulation and the importance of microRNA and posttranscriptional regulation of WNT signaling are also reviewed.
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spelling pubmed-55843422017-09-06 WNT signaling – lung cancer is no exception Rapp, Judit Jaromi, Luca Kvell, Krisztian Miskei, Gyorgy Pongracz, Judit E. Respir Res Review Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the various effects of activation and inhibition of the WNT signaling pathways are summarized in the context of lung carcinogenesis. Recent evidence regarding WNT ligand transport mechanisms, the role of WNT signaling in lung cancer angiogenesis and drug transporter regulation and the importance of microRNA and posttranscriptional regulation of WNT signaling are also reviewed. BioMed Central 2017-09-05 2017 /pmc/articles/PMC5584342/ /pubmed/28870231 http://dx.doi.org/10.1186/s12931-017-0650-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Rapp, Judit
Jaromi, Luca
Kvell, Krisztian
Miskei, Gyorgy
Pongracz, Judit E.
WNT signaling – lung cancer is no exception
title WNT signaling – lung cancer is no exception
title_full WNT signaling – lung cancer is no exception
title_fullStr WNT signaling – lung cancer is no exception
title_full_unstemmed WNT signaling – lung cancer is no exception
title_short WNT signaling – lung cancer is no exception
title_sort wnt signaling – lung cancer is no exception
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584342/
https://www.ncbi.nlm.nih.gov/pubmed/28870231
http://dx.doi.org/10.1186/s12931-017-0650-6
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