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MicroRNA Profiling in Cartilage Ageing
Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584353/ https://www.ncbi.nlm.nih.gov/pubmed/28890892 http://dx.doi.org/10.1155/2017/2713725 |
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author | Balaskas, Panagiotis Goljanek-Whysall, Katarzyna Clegg, Peter Fang, Yongxiang Cremers, Andy Emans, Pieter Welting, Tim Peffers, Mandy |
author_facet | Balaskas, Panagiotis Goljanek-Whysall, Katarzyna Clegg, Peter Fang, Yongxiang Cremers, Andy Emans, Pieter Welting, Tim Peffers, Mandy |
author_sort | Balaskas, Panagiotis |
collection | PubMed |
description | Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets. |
format | Online Article Text |
id | pubmed-5584353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55843532017-09-10 MicroRNA Profiling in Cartilage Ageing Balaskas, Panagiotis Goljanek-Whysall, Katarzyna Clegg, Peter Fang, Yongxiang Cremers, Andy Emans, Pieter Welting, Tim Peffers, Mandy Int J Genomics Research Article Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets. Hindawi 2017 2017-08-14 /pmc/articles/PMC5584353/ /pubmed/28890892 http://dx.doi.org/10.1155/2017/2713725 Text en Copyright © 2017 Panagiotis Balaskas et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Balaskas, Panagiotis Goljanek-Whysall, Katarzyna Clegg, Peter Fang, Yongxiang Cremers, Andy Emans, Pieter Welting, Tim Peffers, Mandy MicroRNA Profiling in Cartilage Ageing |
title | MicroRNA Profiling in Cartilage Ageing |
title_full | MicroRNA Profiling in Cartilage Ageing |
title_fullStr | MicroRNA Profiling in Cartilage Ageing |
title_full_unstemmed | MicroRNA Profiling in Cartilage Ageing |
title_short | MicroRNA Profiling in Cartilage Ageing |
title_sort | microrna profiling in cartilage ageing |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584353/ https://www.ncbi.nlm.nih.gov/pubmed/28890892 http://dx.doi.org/10.1155/2017/2713725 |
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