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Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations
Transcriptional mutagenesis (TM) due to misincorporation during RNA transcription can result in mutant RNAs, or epimutations, that generate proteins with altered properties. TM has long been hypothesized to play a role in aging, cancer, and viral and bacterial evolution. However, inadequate methodol...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584456/ https://www.ncbi.nlm.nih.gov/pubmed/28798064 http://dx.doi.org/10.1073/pnas.1709166114 |