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Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up

Hairy B-cell lymphoproliferative disorder (HBLD) is one of chronic polyclonal B-cell lymphocytosis. We report a 47-year-old female Japanese patient diagnosed as having HBLD based on lymphocytosis with hairy cell appearance and characteristic phenotypes including CD11c+ and without B-cell monoclonali...

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Autores principales: Matsuda, Kensuke, Matsumoto, Yosuke, Yoshida, Mihoko, Shimura, Kazuho, Kaneko, Hiroto, Inaba, Tohru, Horiike, Shigeo, Kuroda, Junya, Taniwaki, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584765/
https://www.ncbi.nlm.nih.gov/pubmed/28894563
http://dx.doi.org/10.4084/MJHID.2017.054
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author Matsuda, Kensuke
Matsumoto, Yosuke
Yoshida, Mihoko
Shimura, Kazuho
Kaneko, Hiroto
Inaba, Tohru
Horiike, Shigeo
Kuroda, Junya
Taniwaki, Masafumi
author_facet Matsuda, Kensuke
Matsumoto, Yosuke
Yoshida, Mihoko
Shimura, Kazuho
Kaneko, Hiroto
Inaba, Tohru
Horiike, Shigeo
Kuroda, Junya
Taniwaki, Masafumi
author_sort Matsuda, Kensuke
collection PubMed
description Hairy B-cell lymphoproliferative disorder (HBLD) is one of chronic polyclonal B-cell lymphocytosis. We report a 47-year-old female Japanese patient diagnosed as having HBLD based on lymphocytosis with hairy cell appearance and characteristic phenotypes including CD11c+ and without B-cell monoclonality. She was a non-smoker and possessed HLA-DR4. She has been closely followed up without treatment and lymphoma development for over five years. Although this disease is quite rare and has been reported, to our knowledge, in only 13 Japanese cases, an accurate diagnosis, particularly differential diagnosis from persistent polyclonal B-cell lymphocytosis or hairy cell leukemia-Japanese variant is essential for the prevention of unnecessary treatments.
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spelling pubmed-55847652017-09-11 Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up Matsuda, Kensuke Matsumoto, Yosuke Yoshida, Mihoko Shimura, Kazuho Kaneko, Hiroto Inaba, Tohru Horiike, Shigeo Kuroda, Junya Taniwaki, Masafumi Mediterr J Hematol Infect Dis Case Report Hairy B-cell lymphoproliferative disorder (HBLD) is one of chronic polyclonal B-cell lymphocytosis. We report a 47-year-old female Japanese patient diagnosed as having HBLD based on lymphocytosis with hairy cell appearance and characteristic phenotypes including CD11c+ and without B-cell monoclonality. She was a non-smoker and possessed HLA-DR4. She has been closely followed up without treatment and lymphoma development for over five years. Although this disease is quite rare and has been reported, to our knowledge, in only 13 Japanese cases, an accurate diagnosis, particularly differential diagnosis from persistent polyclonal B-cell lymphocytosis or hairy cell leukemia-Japanese variant is essential for the prevention of unnecessary treatments. Università Cattolica del Sacro Cuore 2017-09-01 /pmc/articles/PMC5584765/ /pubmed/28894563 http://dx.doi.org/10.4084/MJHID.2017.054 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Matsuda, Kensuke
Matsumoto, Yosuke
Yoshida, Mihoko
Shimura, Kazuho
Kaneko, Hiroto
Inaba, Tohru
Horiike, Shigeo
Kuroda, Junya
Taniwaki, Masafumi
Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up
title Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up
title_full Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up
title_fullStr Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up
title_full_unstemmed Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up
title_short Hairy B-Cell Lymphoproliferative Disorder and its Differential Diagnosis: a Case with Long-Term Follow-Up
title_sort hairy b-cell lymphoproliferative disorder and its differential diagnosis: a case with long-term follow-up
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584765/
https://www.ncbi.nlm.nih.gov/pubmed/28894563
http://dx.doi.org/10.4084/MJHID.2017.054
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