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Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK

The drug 2-hydroxypropyl-β-cyclodextrin (HPβCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease, type C (NPC) and has been advanced to human clinical trials. However, its mechanism of action for reducing cholesterol accumulation in NPC cells is uncertain and its molecular target i...

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Detalles Bibliográficos
Autores principales:	Dai, Sheng, Dulcey, Andrés E., Hu, Xin, Wassif, Christopher A., Porter, Forbes D., Austin, Christopher P., Ory, Daniel S., Marugan, Juan, Zheng, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Translational Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584846/ https://www.ncbi.nlm.nih.gov/pubmed/28613987 http://dx.doi.org/10.1080/15548627.2017.1329081

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