Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases

Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar structures, acquire aberrant (misfolded) conformations toxic to cells. To prevent misfolded protein toxicity, cells activate...

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Detalles Bibliográficos
Autores principales: Cristofani, Riccardo, Crippa, Valeria, Rusmini, Paola, Cicardi, Maria Elena, Meroni, Marco, Licata, Nausicaa V., Sala, Gessica, Giorgetti, Elisa, Grunseich, Christopher, Galbiati, Mariarita, Piccolella, Margherita, Messi, Elio, Ferrarese, Carlo, Carra, Serena, Poletti, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584856/
https://www.ncbi.nlm.nih.gov/pubmed/28402699
http://dx.doi.org/10.1080/15548627.2017.1308985

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