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A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data
BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the va...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584892/ https://www.ncbi.nlm.nih.gov/pubmed/28894396 http://dx.doi.org/10.2147/POR.S140579 |
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author | Kern, David M Barron, John J Wu, Bingcao Ganetsky, Alex Willey, Vincent J Quimbo, Ralph A Fisch, Michael J Singer, Joseph Nguyen, Ann Mamtani, Ronac |
author_facet | Kern, David M Barron, John J Wu, Bingcao Ganetsky, Alex Willey, Vincent J Quimbo, Ralph A Fisch, Michael J Singer, Joseph Nguyen, Ann Mamtani, Ronac |
author_sort | Kern, David M |
collection | PubMed |
description | BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the validity of the HIRE-Oncology data compared with medical records of breast, lung, and colorectal cancer patients. METHODS: Data elements included cancer type, stage, histology (lung only), and biomarkers. A sample of 300 breast, 200 lung, and 200 colorectal cancer patients within the HIRE-Oncology data were identified for medical record review. Statistical measures of validity (agreement, positive predictive value [PPV], negative predictive value [NPV], sensitivity, specificity) were used to compare clinical information between data sources, with medical record data considered the gold standard. RESULTS: All 300 breast cancer records reviewed were confirmed breast cancer, while 197 lung and 197 colorectal records were confirmed (PPV =0.99 for each). The agreement of disease stage was 85% for breast, 90% for lung, and 94% for colorectal cancer. The agreement of lung cancer histology (small cell vs non-small cell) was 97%. Agreement of progesterone receptor, estrogen receptor, and human epidermal growth factor receptor 2 status biomarkers in breast cancer was 92%, 97%, and 92%, respectively; epidermal growth factor receptor and anaplastic lymphoma kinase agreement in lung was 97% and 92%, respectively; and agreement of KRAS status in colorectal cancer was 95%. Measures of PPV, NPV, sensitivity, and specificity showed similarly strong evidence of validity. CONCLUSION: Good agreement between the HIRE-Oncology data and medical records supports the validity of these data for research. |
format | Online Article Text |
id | pubmed-5584892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55848922017-09-11 A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data Kern, David M Barron, John J Wu, Bingcao Ganetsky, Alex Willey, Vincent J Quimbo, Ralph A Fisch, Michael J Singer, Joseph Nguyen, Ann Mamtani, Ronac Pragmat Obs Res Original Research BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the validity of the HIRE-Oncology data compared with medical records of breast, lung, and colorectal cancer patients. METHODS: Data elements included cancer type, stage, histology (lung only), and biomarkers. A sample of 300 breast, 200 lung, and 200 colorectal cancer patients within the HIRE-Oncology data were identified for medical record review. Statistical measures of validity (agreement, positive predictive value [PPV], negative predictive value [NPV], sensitivity, specificity) were used to compare clinical information between data sources, with medical record data considered the gold standard. RESULTS: All 300 breast cancer records reviewed were confirmed breast cancer, while 197 lung and 197 colorectal records were confirmed (PPV =0.99 for each). The agreement of disease stage was 85% for breast, 90% for lung, and 94% for colorectal cancer. The agreement of lung cancer histology (small cell vs non-small cell) was 97%. Agreement of progesterone receptor, estrogen receptor, and human epidermal growth factor receptor 2 status biomarkers in breast cancer was 92%, 97%, and 92%, respectively; epidermal growth factor receptor and anaplastic lymphoma kinase agreement in lung was 97% and 92%, respectively; and agreement of KRAS status in colorectal cancer was 95%. Measures of PPV, NPV, sensitivity, and specificity showed similarly strong evidence of validity. CONCLUSION: Good agreement between the HIRE-Oncology data and medical records supports the validity of these data for research. Dove Medical Press 2017-08-26 /pmc/articles/PMC5584892/ /pubmed/28894396 http://dx.doi.org/10.2147/POR.S140579 Text en © 2017 Kern et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Kern, David M Barron, John J Wu, Bingcao Ganetsky, Alex Willey, Vincent J Quimbo, Ralph A Fisch, Michael J Singer, Joseph Nguyen, Ann Mamtani, Ronac A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data |
title | A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data |
title_full | A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data |
title_fullStr | A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data |
title_full_unstemmed | A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data |
title_short | A validation of clinical data captured from a novel Cancer Care Quality Program directly integrated with administrative claims data |
title_sort | validation of clinical data captured from a novel cancer care quality program directly integrated with administrative claims data |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584892/ https://www.ncbi.nlm.nih.gov/pubmed/28894396 http://dx.doi.org/10.2147/POR.S140579 |
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