Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling

We have reported that integrins crosstalk with growth factors through direct binding to growth factors (e.g., fibroblast growth factor-1, insulin-like growth factor 1 (IGF1), neuregulin-1, fractalkine) and subsequent ternary complex formation with cognate receptor [e.g., integrin/IGF1/IGF1 receptor...

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Detalles Bibliográficos
Autores principales: Cedano Prieto, Dora Maria, Cheng, Yushen, Chang, Chih-Chieh, Yu, Jessica, Takada, Yoko K., Takada, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584928/
https://www.ncbi.nlm.nih.gov/pubmed/28873464
http://dx.doi.org/10.1371/journal.pone.0184285

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