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Magnetic eye tracking in mice

Eye movements provide insights about a wide range of brain functions, from sensorimotor integration to cognition; hence, the measurement of eye movements is an important tool in neuroscience research. We describe a method, based on magnetic sensing, for measuring eye movements in head-fixed and free...

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Detalles Bibliográficos
Autores principales: Payne, Hannah L, Raymond, Jennifer L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584990/
https://www.ncbi.nlm.nih.gov/pubmed/28872455
http://dx.doi.org/10.7554/eLife.29222
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author Payne, Hannah L
Raymond, Jennifer L
author_facet Payne, Hannah L
Raymond, Jennifer L
author_sort Payne, Hannah L
collection PubMed
description Eye movements provide insights about a wide range of brain functions, from sensorimotor integration to cognition; hence, the measurement of eye movements is an important tool in neuroscience research. We describe a method, based on magnetic sensing, for measuring eye movements in head-fixed and freely moving mice. A small magnet was surgically implanted on the eye, and changes in the magnet angle as the eye rotated were detected by a magnetic field sensor. Systematic testing demonstrated high resolution measurements of eye position of <0.1°. Magnetic eye tracking offers several advantages over the well-established eye coil and video-oculography methods. Most notably, it provides the first method for reliable, high-resolution measurement of eye movements in freely moving mice, revealing increased eye movements and altered binocular coordination compared to head-fixed mice. Overall, magnetic eye tracking provides a lightweight, inexpensive, easily implemented, and high-resolution method suitable for a wide range of applications.
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spelling pubmed-55849902017-09-06 Magnetic eye tracking in mice Payne, Hannah L Raymond, Jennifer L eLife Neuroscience Eye movements provide insights about a wide range of brain functions, from sensorimotor integration to cognition; hence, the measurement of eye movements is an important tool in neuroscience research. We describe a method, based on magnetic sensing, for measuring eye movements in head-fixed and freely moving mice. A small magnet was surgically implanted on the eye, and changes in the magnet angle as the eye rotated were detected by a magnetic field sensor. Systematic testing demonstrated high resolution measurements of eye position of <0.1°. Magnetic eye tracking offers several advantages over the well-established eye coil and video-oculography methods. Most notably, it provides the first method for reliable, high-resolution measurement of eye movements in freely moving mice, revealing increased eye movements and altered binocular coordination compared to head-fixed mice. Overall, magnetic eye tracking provides a lightweight, inexpensive, easily implemented, and high-resolution method suitable for a wide range of applications. eLife Sciences Publications, Ltd 2017-09-05 /pmc/articles/PMC5584990/ /pubmed/28872455 http://dx.doi.org/10.7554/eLife.29222 Text en © 2017, Payne et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Payne, Hannah L
Raymond, Jennifer L
Magnetic eye tracking in mice
title Magnetic eye tracking in mice
title_full Magnetic eye tracking in mice
title_fullStr Magnetic eye tracking in mice
title_full_unstemmed Magnetic eye tracking in mice
title_short Magnetic eye tracking in mice
title_sort magnetic eye tracking in mice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584990/
https://www.ncbi.nlm.nih.gov/pubmed/28872455
http://dx.doi.org/10.7554/eLife.29222
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