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Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates

Phospholipid flippases (P(4)-ATPases) translocate specific phospholipids from the exoplasmic to the cytoplasmic leaflet of membranes. While there is good evidence that the overall molecular structure of flippases is similar to that of P-type ATPase ion-pumps, the transport pathway for the “giant” li...

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Detalles Bibliográficos
Autores principales:	Gantzel, Rasmus H., Mogensen, Louise S., Mikkelsen, Stine A., Vilsen, Bente, Molday, Robert S., Vestergaard, Anna L., Andersen, Jens P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585164/ https://www.ncbi.nlm.nih.gov/pubmed/28874751 http://dx.doi.org/10.1038/s41598-017-10741-z

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