Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment

Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and cellular tumor microenvironment which suppresses adoptively transferred T cells. We engineered an armo...

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Detalles Bibliográficos
Autores principales: Yeku, Oladapo O., Purdon, Terence J., Koneru, Mythili, Spriggs, David, Brentjens, Renier J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585170/
https://www.ncbi.nlm.nih.gov/pubmed/28874817
http://dx.doi.org/10.1038/s41598-017-10940-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585170/
https://www.ncbi.nlm.nih.gov/pubmed/28874817
http://dx.doi.org/10.1038/s41598-017-10940-8

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