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The Detection of Phase Amplitude Coupling during Sensory Processing

There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or p...

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Autores principales: Seymour, Robert A., Rippon, Gina, Kessler, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585190/
https://www.ncbi.nlm.nih.gov/pubmed/28919850
http://dx.doi.org/10.3389/fnins.2017.00487
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author Seymour, Robert A.
Rippon, Gina
Kessler, Klaus
author_facet Seymour, Robert A.
Rippon, Gina
Kessler, Klaus
author_sort Seymour, Robert A.
collection PubMed
description There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequency oscillations during certain tasks, termed phase amplitude coupling (PAC). For instance, during visual processing in humans, PAC has been reliably observed between ongoing alpha (8–13 Hz) and gamma-band (>40 Hz) activity. However, the application of PAC metrics to electrophysiological data can be challenging due to numerous methodological issues and lack of coherent approaches within the field. Therefore, in this article we outline the various analysis steps involved in detecting PAC, using an openly available MEG dataset from 16 participants performing an interactive visual task. Firstly, we localized gamma and alpha-band power using the Fieldtrip toolbox, and extracted time courses from area V1, defined using a multimodal parcelation scheme. These V1 responses were analyzed for changes in alpha-gamma PAC, using four common algorithms. Results showed an increase in alpha (7–13 Hz)–gamma (40–100 Hz) PAC in response to the visual grating stimulus, though specific patterns of coupling were somewhat dependent upon the algorithm employed. Additionally, post-hoc analyses showed that these results were not driven by the presence of non-sinusoidal oscillations, and that trial length was sufficient to obtain reliable PAC estimates. Finally, throughout the article, methodological issues and practical guidelines for ongoing PAC research will be discussed.
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spelling pubmed-55851902017-09-15 The Detection of Phase Amplitude Coupling during Sensory Processing Seymour, Robert A. Rippon, Gina Kessler, Klaus Front Neurosci Neuroscience There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequency oscillations during certain tasks, termed phase amplitude coupling (PAC). For instance, during visual processing in humans, PAC has been reliably observed between ongoing alpha (8–13 Hz) and gamma-band (>40 Hz) activity. However, the application of PAC metrics to electrophysiological data can be challenging due to numerous methodological issues and lack of coherent approaches within the field. Therefore, in this article we outline the various analysis steps involved in detecting PAC, using an openly available MEG dataset from 16 participants performing an interactive visual task. Firstly, we localized gamma and alpha-band power using the Fieldtrip toolbox, and extracted time courses from area V1, defined using a multimodal parcelation scheme. These V1 responses were analyzed for changes in alpha-gamma PAC, using four common algorithms. Results showed an increase in alpha (7–13 Hz)–gamma (40–100 Hz) PAC in response to the visual grating stimulus, though specific patterns of coupling were somewhat dependent upon the algorithm employed. Additionally, post-hoc analyses showed that these results were not driven by the presence of non-sinusoidal oscillations, and that trial length was sufficient to obtain reliable PAC estimates. Finally, throughout the article, methodological issues and practical guidelines for ongoing PAC research will be discussed. Frontiers Media S.A. 2017-09-01 /pmc/articles/PMC5585190/ /pubmed/28919850 http://dx.doi.org/10.3389/fnins.2017.00487 Text en Copyright © 2017 Seymour, Rippon and Kessler. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Seymour, Robert A.
Rippon, Gina
Kessler, Klaus
The Detection of Phase Amplitude Coupling during Sensory Processing
title The Detection of Phase Amplitude Coupling during Sensory Processing
title_full The Detection of Phase Amplitude Coupling during Sensory Processing
title_fullStr The Detection of Phase Amplitude Coupling during Sensory Processing
title_full_unstemmed The Detection of Phase Amplitude Coupling during Sensory Processing
title_short The Detection of Phase Amplitude Coupling during Sensory Processing
title_sort detection of phase amplitude coupling during sensory processing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585190/
https://www.ncbi.nlm.nih.gov/pubmed/28919850
http://dx.doi.org/10.3389/fnins.2017.00487
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