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SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε

Viruses modulate the host immune system to evade host antiviral responses. The poxvirus proteins serine proteinase inhibitor 2 (SPI-2) and cytokine response modifier A (CrmA) are involved in multiple poxvirus evasion strategies. SPI-2 and CrmA target caspase-1 to prevent apoptosis and cytokine activ...

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Detalles Bibliográficos
Autores principales:	Qin, Yue, Li, Mi, Zhou, Sheng-Long, Yin, Wei, Bian, Zhuan, Shu, Hong-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585206/ https://www.ncbi.nlm.nih.gov/pubmed/28874755 http://dx.doi.org/10.1038/s41598-017-11016-3

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