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Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters

Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with and with no RLS (PD-RLS and PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor and non...

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Autores principales: Piao, Ying-Shan, Lian, Teng-Hong, Hu, Yang, Zuo, Li-Jun, Guo, Peng, Yu, Shu-Yang, Liu, Li, Jin, Zhao, Zhao, Hui, Li, Li-Xia, yu, Qiu-Jin, Wang, Rui-Dan, Chen, Sheng-Di, Chan, Piu, Wang, Xiao-Min, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585207/
https://www.ncbi.nlm.nih.gov/pubmed/28874701
http://dx.doi.org/10.1038/s41598-017-10593-7
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author Piao, Ying-Shan
Lian, Teng-Hong
Hu, Yang
Zuo, Li-Jun
Guo, Peng
Yu, Shu-Yang
Liu, Li
Jin, Zhao
Zhao, Hui
Li, Li-Xia
yu, Qiu-Jin
Wang, Rui-Dan
Chen, Sheng-Di
Chan, Piu
Wang, Xiao-Min
Zhang, Wei
author_facet Piao, Ying-Shan
Lian, Teng-Hong
Hu, Yang
Zuo, Li-Jun
Guo, Peng
Yu, Shu-Yang
Liu, Li
Jin, Zhao
Zhao, Hui
Li, Li-Xia
yu, Qiu-Jin
Wang, Rui-Dan
Chen, Sheng-Di
Chan, Piu
Wang, Xiao-Min
Zhang, Wei
author_sort Piao, Ying-Shan
collection PubMed
description Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with and with no RLS (PD-RLS and PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor and non-motor symptoms were rated by related scales. Iron and related proteins, and neurotransmitters in cerebrospinal fluid (CSF) and serum were measured. PD-RLS frequency was 40.37%. PD-RLS group had longer duration, higher stage and scores of motor symptoms, depression, anxiety, sleep disorders, fatigue and apathy, and increased transferrin and decreased iron, ferritin, dopamine (DA) and 5-hydroxytryptamine (5-HT) in CSF. In CSF of PD-RLS group, RLS-RS score was positively correlated with transferrin level and negatively correlated with iron and ferritin levels; RLS-RS score was negatively correlated with DA and 5-HT levels; transferrin level was negatively correlated with DA and 5-HT levels, and ferritin level was positively correlated with DA level. In serum, PD-RLS group had decreased iron and transferrin levels, which were negatively correlated with RLS-RS score. PD-RLS was common and severer in motor and some non-motor symptoms. Iron deficiency induced by its metabolism dysfunctions in peripheral and central systems might cause PD-RLS through decreasing brain DA and 5-HT.
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spelling pubmed-55852072017-09-06 Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters Piao, Ying-Shan Lian, Teng-Hong Hu, Yang Zuo, Li-Jun Guo, Peng Yu, Shu-Yang Liu, Li Jin, Zhao Zhao, Hui Li, Li-Xia yu, Qiu-Jin Wang, Rui-Dan Chen, Sheng-Di Chan, Piu Wang, Xiao-Min Zhang, Wei Sci Rep Article Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with and with no RLS (PD-RLS and PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor and non-motor symptoms were rated by related scales. Iron and related proteins, and neurotransmitters in cerebrospinal fluid (CSF) and serum were measured. PD-RLS frequency was 40.37%. PD-RLS group had longer duration, higher stage and scores of motor symptoms, depression, anxiety, sleep disorders, fatigue and apathy, and increased transferrin and decreased iron, ferritin, dopamine (DA) and 5-hydroxytryptamine (5-HT) in CSF. In CSF of PD-RLS group, RLS-RS score was positively correlated with transferrin level and negatively correlated with iron and ferritin levels; RLS-RS score was negatively correlated with DA and 5-HT levels; transferrin level was negatively correlated with DA and 5-HT levels, and ferritin level was positively correlated with DA level. In serum, PD-RLS group had decreased iron and transferrin levels, which were negatively correlated with RLS-RS score. PD-RLS was common and severer in motor and some non-motor symptoms. Iron deficiency induced by its metabolism dysfunctions in peripheral and central systems might cause PD-RLS through decreasing brain DA and 5-HT. Nature Publishing Group UK 2017-09-05 /pmc/articles/PMC5585207/ /pubmed/28874701 http://dx.doi.org/10.1038/s41598-017-10593-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Piao, Ying-Shan
Lian, Teng-Hong
Hu, Yang
Zuo, Li-Jun
Guo, Peng
Yu, Shu-Yang
Liu, Li
Jin, Zhao
Zhao, Hui
Li, Li-Xia
yu, Qiu-Jin
Wang, Rui-Dan
Chen, Sheng-Di
Chan, Piu
Wang, Xiao-Min
Zhang, Wei
Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
title Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
title_full Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
title_fullStr Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
title_full_unstemmed Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
title_short Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
title_sort restless legs syndrome in parkinson disease: clinical characteristics, abnormal iron metabolism and altered neurotransmitters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585207/
https://www.ncbi.nlm.nih.gov/pubmed/28874701
http://dx.doi.org/10.1038/s41598-017-10593-7
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