Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baits

Ultrasensitive methods for rare allele detection are critical to leverage the full potential offered by liquid biopsies. Here, we describe a novel molecular barcoding method for the precise detection and quantification of circulating tumor DNA (ctDNA). The major benefits of our design include straig...

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Detalles Bibliográficos
Autores principales: Alcaide, Miguel, Yu, Stephen, Davidson, Jordan, Albuquerque, Marco, Bushell, Kevin, Fornika, Daniel, Arthur, Sarah, Grande, Bruno M., McNamara, Suzan, Tertre, Mathilde Couetoux du, Batist, Gerald, Huntsman, David G., Cavallone, Luca, Aguilar, Adriana, Basik, Mark, Johnson, Nathalie A., Deyell, Rebecca J., Rassekh, S. Rod, Morin, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585219/
https://www.ncbi.nlm.nih.gov/pubmed/28874686
http://dx.doi.org/10.1038/s41598-017-10269-2

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