RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury

Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage, and the upregulation of inhibitory molecules which prevent regeneration and limit recovery. Repulsive guidance molecule A (RGMa) is a potent neurite growth inhibitor in the central nervous...

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Detalles Bibliográficos
Autores principales: Mothe, Andrea J., Tassew, Nardos G., Shabanzadeh, Alirezha P., Penheiro, Romeo, Vigouroux, Robin J., Huang, Lili, Grinnell, Christine, Cui, Yi-Fang, Fung, Emma, Monnier, Philippe P., Mueller, Bernhard K., Tator, Charles H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585220/
https://www.ncbi.nlm.nih.gov/pubmed/28874746
http://dx.doi.org/10.1038/s41598-017-10987-7

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