Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel

TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 mechano/osmosensitivity depends on phospholipase A(2) (PLA(2)) activation and subseq...

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Detalles Bibliográficos
Autores principales: Berna-Erro, Alejandro, Izquierdo-Serra, Mercè, Sepúlveda, Romina V., Rubio-Moscardo, Fanny, Doñate-Macián, Pau, Serra, Selma A., Carrillo-Garcia, Julia, Perálvarez-Marín, Alex, González-Nilo, Fernando, Fernández-Fernández, José M., Valverde, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585255/
https://www.ncbi.nlm.nih.gov/pubmed/28874838
http://dx.doi.org/10.1038/s41598-017-11274-1

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