Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

Developmental genes in metazoan genomes are surrounded by dense clusters of conserved noncoding elements (CNEs). CNEs exhibit unexplained extreme levels of sequence conservation, with many acting as developmental long-range enhancers. Clusters of CNEs define the span of regulatory inputs for many im...

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Detalles Bibliográficos
Autores principales: Harmston, Nathan, Ing-Simmons, Elizabeth, Tan, Ge, Perry, Malcolm, Merkenschlager, Matthias, Lenhard, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585340/
https://www.ncbi.nlm.nih.gov/pubmed/28874668
http://dx.doi.org/10.1038/s41467-017-00524-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585340/
https://www.ncbi.nlm.nih.gov/pubmed/28874668
http://dx.doi.org/10.1038/s41467-017-00524-5

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