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Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
Developmental genes in metazoan genomes are surrounded by dense clusters of conserved noncoding elements (CNEs). CNEs exhibit unexplained extreme levels of sequence conservation, with many acting as developmental long-range enhancers. Clusters of CNEs define the span of regulatory inputs for many im...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585340/ https://www.ncbi.nlm.nih.gov/pubmed/28874668 http://dx.doi.org/10.1038/s41467-017-00524-5 |