Internalized TSH receptors en route to the TGN induce local G(s)-protein signaling and gene transcription

A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely...

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Detalles Bibliográficos
Autores principales: Godbole, Amod, Lyga, Sandra, Lohse, Martin J., Calebiro, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585343/
https://www.ncbi.nlm.nih.gov/pubmed/28874659
http://dx.doi.org/10.1038/s41467-017-00357-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585343/
https://www.ncbi.nlm.nih.gov/pubmed/28874659
http://dx.doi.org/10.1038/s41467-017-00357-2

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