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Internalized TSH receptors en route to the TGN induce local G(s)-protein signaling and gene transcription
A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585343/ https://www.ncbi.nlm.nih.gov/pubmed/28874659 http://dx.doi.org/10.1038/s41467-017-00357-2 |