Cargando…

Prenatal noise stress impairs HPA axis and cognitive performance in mice

Noise stress is a common environmental pollutant whose adverse effect on offspring performance has been less studied. This study was novel in terms of using “noise” as a prenatal stress compared with physical stress to explore the effect of stress during gestation on HPA axis activation, cognitive p...

Descripción completa

Detalles Bibliográficos
Autores principales: Jafari, Zahra, Mehla, Jogender, Kolb, Bryan E., Mohajerani, Majid H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585382/
https://www.ncbi.nlm.nih.gov/pubmed/28874680
http://dx.doi.org/10.1038/s41598-017-09799-6
_version_ 1783261612977684480
author Jafari, Zahra
Mehla, Jogender
Kolb, Bryan E.
Mohajerani, Majid H.
author_facet Jafari, Zahra
Mehla, Jogender
Kolb, Bryan E.
Mohajerani, Majid H.
author_sort Jafari, Zahra
collection PubMed
description Noise stress is a common environmental pollutant whose adverse effect on offspring performance has been less studied. This study was novel in terms of using “noise” as a prenatal stress compared with physical stress to explore the effect of stress during gestation on HPA axis activation, cognitive performance, and motor coordination, as well as in investigating the effect of behavioral assessments on the corticosterone (CORT) levels. Three groups of C57BL/6 mice with a gestational history of either noise stress (NS), physical stress (PS), or no stress were examined in several behavioral tests. Plasma CORT level was significantly higher before starting the behavioral tests in NS group than the two other groups. It was significantly increased after the behavioral tests in both prenatal stressed groups relative to the controls. Stress caused anxiety-like behavior and reduced learning and memory performance in both stressed groups compared to the controls, as well as decreased motor coordination in the NS group relative to the other groups. The findings suggested that: prenatal NS severely changes the HPA axis; both prenatal stressors, and particularly NS, negatively impair the offspring’s cognitive and motor performance; and, they also cause a strong susceptibility to interpret environmental experiences as stressful conditions.
format Online
Article
Text
id pubmed-5585382
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-55853822017-09-06 Prenatal noise stress impairs HPA axis and cognitive performance in mice Jafari, Zahra Mehla, Jogender Kolb, Bryan E. Mohajerani, Majid H. Sci Rep Article Noise stress is a common environmental pollutant whose adverse effect on offspring performance has been less studied. This study was novel in terms of using “noise” as a prenatal stress compared with physical stress to explore the effect of stress during gestation on HPA axis activation, cognitive performance, and motor coordination, as well as in investigating the effect of behavioral assessments on the corticosterone (CORT) levels. Three groups of C57BL/6 mice with a gestational history of either noise stress (NS), physical stress (PS), or no stress were examined in several behavioral tests. Plasma CORT level was significantly higher before starting the behavioral tests in NS group than the two other groups. It was significantly increased after the behavioral tests in both prenatal stressed groups relative to the controls. Stress caused anxiety-like behavior and reduced learning and memory performance in both stressed groups compared to the controls, as well as decreased motor coordination in the NS group relative to the other groups. The findings suggested that: prenatal NS severely changes the HPA axis; both prenatal stressors, and particularly NS, negatively impair the offspring’s cognitive and motor performance; and, they also cause a strong susceptibility to interpret environmental experiences as stressful conditions. Nature Publishing Group UK 2017-09-05 /pmc/articles/PMC5585382/ /pubmed/28874680 http://dx.doi.org/10.1038/s41598-017-09799-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jafari, Zahra
Mehla, Jogender
Kolb, Bryan E.
Mohajerani, Majid H.
Prenatal noise stress impairs HPA axis and cognitive performance in mice
title Prenatal noise stress impairs HPA axis and cognitive performance in mice
title_full Prenatal noise stress impairs HPA axis and cognitive performance in mice
title_fullStr Prenatal noise stress impairs HPA axis and cognitive performance in mice
title_full_unstemmed Prenatal noise stress impairs HPA axis and cognitive performance in mice
title_short Prenatal noise stress impairs HPA axis and cognitive performance in mice
title_sort prenatal noise stress impairs hpa axis and cognitive performance in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585382/
https://www.ncbi.nlm.nih.gov/pubmed/28874680
http://dx.doi.org/10.1038/s41598-017-09799-6
work_keys_str_mv AT jafarizahra prenatalnoisestressimpairshpaaxisandcognitiveperformanceinmice
AT mehlajogender prenatalnoisestressimpairshpaaxisandcognitiveperformanceinmice
AT kolbbryane prenatalnoisestressimpairshpaaxisandcognitiveperformanceinmice
AT mohajeranimajidh prenatalnoisestressimpairshpaaxisandcognitiveperformanceinmice