Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer

Efforts to identify driver mutations in cancer have largely focused on genes, whereas non-coding sequences remain relatively unexplored. Here we develop a statistical method based on characteristics known to influence local mutation rate and a series of enrichment filters in order to identify distal...

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Detalles Bibliográficos
Autores principales: D′Antonio, Matteo, Weghorn, Donate, D′Antonio-Chronowska, Agnieszka, Coulet, Florence, Olson, Katrina M., DeBoever, Christopher, Drees, Frauke, Arias, Angelo, Alakus, Hakan, Richardson, Andrea L., Schwab, Richard B., Farley, Emma K., Sunyaev, Shamil R., Frazer, Kelly A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585396/
https://www.ncbi.nlm.nih.gov/pubmed/28874753
http://dx.doi.org/10.1038/s41467-017-00100-x

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