Pathophysiology of Keratoconus: What Do We Know Today

Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological...

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Detalles Bibliográficos
Autores principales: Soiberman, Uri, Foster, James W., Jun, Albert S., Chakravarti, Shukti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585454/
https://www.ncbi.nlm.nih.gov/pubmed/28932341
http://dx.doi.org/10.2174/1874364101711010252
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author Soiberman, Uri
Foster, James W.
Jun, Albert S.
Chakravarti, Shukti
author_facet Soiberman, Uri
Foster, James W.
Jun, Albert S.
Chakravarti, Shukti
author_sort Soiberman, Uri
collection PubMed
description Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.
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spelling pubmed-55854542017-09-20 Pathophysiology of Keratoconus: What Do We Know Today Soiberman, Uri Foster, James W. Jun, Albert S. Chakravarti, Shukti Open Ophthalmol J Article Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways. Bentham Open 2017-07-31 /pmc/articles/PMC5585454/ /pubmed/28932341 http://dx.doi.org/10.2174/1874364101711010252 Text en © 2017 Soiberman et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Soiberman, Uri
Foster, James W.
Jun, Albert S.
Chakravarti, Shukti
Pathophysiology of Keratoconus: What Do We Know Today
title Pathophysiology of Keratoconus: What Do We Know Today
title_full Pathophysiology of Keratoconus: What Do We Know Today
title_fullStr Pathophysiology of Keratoconus: What Do We Know Today
title_full_unstemmed Pathophysiology of Keratoconus: What Do We Know Today
title_short Pathophysiology of Keratoconus: What Do We Know Today
title_sort pathophysiology of keratoconus: what do we know today
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585454/
https://www.ncbi.nlm.nih.gov/pubmed/28932341
http://dx.doi.org/10.2174/1874364101711010252
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