Genetics in Keratoconus – What is New?

BACKGROUND: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysi...

Descripción completa

Detalles Bibliográficos
Autores principales: Moussa, Sarah, Grabner, Günther, Ruckhofer, Josef, Dietrich, Marie, Reitsamer, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585456/
https://www.ncbi.nlm.nih.gov/pubmed/28932336
http://dx.doi.org/10.2174/1874364101711010201
Descripción
Sumario:BACKGROUND: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. CONCLUSION: The review focuses on current knowledge of these genetic risk factors associated with keratoconus.

Ejemplares similares