Genetics in Keratoconus – What is New?

BACKGROUND: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysi...

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Autores principales: Moussa, Sarah, Grabner, Günther, Ruckhofer, Josef, Dietrich, Marie, Reitsamer, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585456/
https://www.ncbi.nlm.nih.gov/pubmed/28932336
http://dx.doi.org/10.2174/1874364101711010201
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author Moussa, Sarah
Grabner, Günther
Ruckhofer, Josef
Dietrich, Marie
Reitsamer, Herbert
author_facet Moussa, Sarah
Grabner, Günther
Ruckhofer, Josef
Dietrich, Marie
Reitsamer, Herbert
author_sort Moussa, Sarah
collection PubMed
description BACKGROUND: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. CONCLUSION: The review focuses on current knowledge of these genetic risk factors associated with keratoconus.
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spelling pubmed-55854562017-09-20 Genetics in Keratoconus – What is New? Moussa, Sarah Grabner, Günther Ruckhofer, Josef Dietrich, Marie Reitsamer, Herbert Open Ophthalmol J Article BACKGROUND: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. CONCLUSION: The review focuses on current knowledge of these genetic risk factors associated with keratoconus. Bentham Open 2017-07-31 /pmc/articles/PMC5585456/ /pubmed/28932336 http://dx.doi.org/10.2174/1874364101711010201 Text en © 2017 Moussa et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Moussa, Sarah
Grabner, Günther
Ruckhofer, Josef
Dietrich, Marie
Reitsamer, Herbert
Genetics in Keratoconus – What is New?
title Genetics in Keratoconus – What is New?
title_full Genetics in Keratoconus – What is New?
title_fullStr Genetics in Keratoconus – What is New?
title_full_unstemmed Genetics in Keratoconus – What is New?
title_short Genetics in Keratoconus – What is New?
title_sort genetics in keratoconus – what is new?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585456/
https://www.ncbi.nlm.nih.gov/pubmed/28932336
http://dx.doi.org/10.2174/1874364101711010201
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