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Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis

PURPOSE: To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. MATERIALS AND METHODS: A comparison of the outcomes of randomized controlled tr...

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Autores principales: Milants, Christophe, Bruyère, Olivier, Kaux, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585615/
https://www.ncbi.nlm.nih.gov/pubmed/28904970
http://dx.doi.org/10.1155/2017/7538604
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author Milants, Christophe
Bruyère, Olivier
Kaux, Jean-François
author_facet Milants, Christophe
Bruyère, Olivier
Kaux, Jean-François
author_sort Milants, Christophe
collection PubMed
description PURPOSE: To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. MATERIALS AND METHODS: A comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality meta-analyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). RESULTS AND DISCUSSION: From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2Bβ in 5/7 studies. The use of PRP with leukocytes is only found in the BRG. CONCLUSION: There is a lack of standardization in PRP preparation technique for knee osteoarthritis. However it appears that the use of a single spinning technique, a platelet concentration lower than 5 times the baseline, and avoidance of leukocytes should be preferred.
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spelling pubmed-55856152017-09-13 Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis Milants, Christophe Bruyère, Olivier Kaux, Jean-François Biomed Res Int Review Article PURPOSE: To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. MATERIALS AND METHODS: A comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality meta-analyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). RESULTS AND DISCUSSION: From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2Bβ in 5/7 studies. The use of PRP with leukocytes is only found in the BRG. CONCLUSION: There is a lack of standardization in PRP preparation technique for knee osteoarthritis. However it appears that the use of a single spinning technique, a platelet concentration lower than 5 times the baseline, and avoidance of leukocytes should be preferred. Hindawi 2017 2017-08-20 /pmc/articles/PMC5585615/ /pubmed/28904970 http://dx.doi.org/10.1155/2017/7538604 Text en Copyright © 2017 Christophe Milants et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Milants, Christophe
Bruyère, Olivier
Kaux, Jean-François
Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis
title Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis
title_full Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis
title_fullStr Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis
title_full_unstemmed Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis
title_short Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis
title_sort responders to platelet-rich plasma in osteoarthritis: a technical analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585615/
https://www.ncbi.nlm.nih.gov/pubmed/28904970
http://dx.doi.org/10.1155/2017/7538604
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