Cargando…
Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients
Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present study assessed the clinical importance of TFAP4 in colorectal c...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585722/ https://www.ncbi.nlm.nih.gov/pubmed/28912857 http://dx.doi.org/10.3892/etm.2017.4875 |
_version_ | 1783261686682091520 |
---|---|
author | Wei, Jianchang Yang, Ping Zhang, Tong Chen, Zhuanpeng Chen, Wei Wanglin, Li He, Feng Wei, Fang Huang, Di Zhong, Junbin Yang, Zhi Chen, Huacui Hu, He Zeng, Shanqi Sun, Zheng Cao, Jie |
author_facet | Wei, Jianchang Yang, Ping Zhang, Tong Chen, Zhuanpeng Chen, Wei Wanglin, Li He, Feng Wei, Fang Huang, Di Zhong, Junbin Yang, Zhi Chen, Huacui Hu, He Zeng, Shanqi Sun, Zheng Cao, Jie |
author_sort | Wei, Jianchang |
collection | PubMed |
description | Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present study assessed the clinical importance of TFAP4 in colorectal cancer (CRC). First, immunohistochemistry was used to analyze TFAP4 expression and the association of TFAP4 expression with clinicopathological features on a tissue microarray containing 208 CRC patients. The results revealed that TFAP4 protein expression was significantly upregulated in CRC tissues compared with that in normal colon tissues (P<0.001). Of note, statistical analysis revealed that TFAP4 expression was significantly correlated with a high pathological grade (P=0.034), advanced clinical stage (P=0.024), enhanced tumor invasion (P=0.002) and lymph node metastasis (P=0.041). In addition, the Cancer Genome Atlas dataset further validated that TFAP4 mRNA levels were increased in CRC with advanced clinical stage (P=0.026), lymph node metastasis (P=0.018) and vascular invasion (P=0.046). Kaplan-Meier survival analysis demonstrated that CRC patients with high TFAP4 expression had shorter overall survival compared with those with low TFAP4 expression (P=0.011). Importantly, overexpression of TFAP4 was a valuable independent prognostic factor for CRC patients (hazard ratio, 8.200; 95% confidence interval, 1.838–36.591; P=0.006). In summary, TFAP4 may have an important role in CRC progression and upregulation of TFAP4 may be a predictor of poor prognosis for CRC patients. |
format | Online Article Text |
id | pubmed-5585722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-55857222017-09-14 Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients Wei, Jianchang Yang, Ping Zhang, Tong Chen, Zhuanpeng Chen, Wei Wanglin, Li He, Feng Wei, Fang Huang, Di Zhong, Junbin Yang, Zhi Chen, Huacui Hu, He Zeng, Shanqi Sun, Zheng Cao, Jie Exp Ther Med Articles Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present study assessed the clinical importance of TFAP4 in colorectal cancer (CRC). First, immunohistochemistry was used to analyze TFAP4 expression and the association of TFAP4 expression with clinicopathological features on a tissue microarray containing 208 CRC patients. The results revealed that TFAP4 protein expression was significantly upregulated in CRC tissues compared with that in normal colon tissues (P<0.001). Of note, statistical analysis revealed that TFAP4 expression was significantly correlated with a high pathological grade (P=0.034), advanced clinical stage (P=0.024), enhanced tumor invasion (P=0.002) and lymph node metastasis (P=0.041). In addition, the Cancer Genome Atlas dataset further validated that TFAP4 mRNA levels were increased in CRC with advanced clinical stage (P=0.026), lymph node metastasis (P=0.018) and vascular invasion (P=0.046). Kaplan-Meier survival analysis demonstrated that CRC patients with high TFAP4 expression had shorter overall survival compared with those with low TFAP4 expression (P=0.011). Importantly, overexpression of TFAP4 was a valuable independent prognostic factor for CRC patients (hazard ratio, 8.200; 95% confidence interval, 1.838–36.591; P=0.006). In summary, TFAP4 may have an important role in CRC progression and upregulation of TFAP4 may be a predictor of poor prognosis for CRC patients. D.A. Spandidos 2017-10 2017-08-02 /pmc/articles/PMC5585722/ /pubmed/28912857 http://dx.doi.org/10.3892/etm.2017.4875 Text en Copyright: © Wei et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wei, Jianchang Yang, Ping Zhang, Tong Chen, Zhuanpeng Chen, Wei Wanglin, Li He, Feng Wei, Fang Huang, Di Zhong, Junbin Yang, Zhi Chen, Huacui Hu, He Zeng, Shanqi Sun, Zheng Cao, Jie Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients |
title | Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients |
title_full | Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients |
title_fullStr | Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients |
title_full_unstemmed | Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients |
title_short | Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients |
title_sort | overexpression of transcription factor activating enhancer binding protein 4 (tfap4) predicts poor prognosis for colorectal cancer patients |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585722/ https://www.ncbi.nlm.nih.gov/pubmed/28912857 http://dx.doi.org/10.3892/etm.2017.4875 |
work_keys_str_mv | AT weijianchang overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT yangping overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT zhangtong overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT chenzhuanpeng overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT chenwei overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT wanglinli overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT hefeng overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT weifang overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT huangdi overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT zhongjunbin overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT yangzhi overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT chenhuacui overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT huhe overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT zengshanqi overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT sunzheng overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients AT caojie overexpressionoftranscriptionfactoractivatingenhancerbindingprotein4tfap4predictspoorprognosisforcolorectalcancerpatients |