Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency

The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate and mouse models. In addition to delaying normative aging, inhibition of mTORC1 extends the shortened lifespan of yeast, fly, and...

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Detalles Bibliográficos
Autores principales: Ito, Takashi K., Lu, Chenhao, Khan, Jacob, Nguyen, Quy, Huang, Heather Z., Kim, Dayae, Phillips, James, Tan, Jo, Lee, Yenna, Nguyen, Tuyet, Khessib, Samy, Lim, Natalie, Mekvanich, Surapat, Oh, Joshua, Pineda, Victor V., Wang, Weirong, Bitto, Alessandro, An, Jonathan Y., Morton, John F., Setou, Mitsutoshi, Ladiges, Warren C., Kaeberlein, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585733/
https://www.ncbi.nlm.nih.gov/pubmed/28919908
http://dx.doi.org/10.3389/fgene.2017.00113

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