Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition

BACKGROUND: Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is still unclear. Because IDO may be modulated by TGF-β1, a potent fibrogenic mol...

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Detalles Bibliográficos
Autores principales: Matheus, Luiz Henrique Gomes, Simão, Gislene Mendes, Amaral, Taíssa Altieri, Brito, Rodrigo Barbosa Oliveira, Malta, Camila Soares, Matos, Yves Silva Teles, Santana, Alexandre Chagas, Rodrigues, Gabriela Gomes Cardoso, Albejante, Maria Clara, Bach, Erna Elisabeth, Dalboni, Maria Aparecida, Camacho, Cleber Pinto, Dellê, Humberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585959/
https://www.ncbi.nlm.nih.gov/pubmed/28877670
http://dx.doi.org/10.1186/s12882-017-0702-7

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