Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

BACKGROUND: Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrogens are mediated through ERβ and insulin-like growth factor 1 signaling to inhi...

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Detalles Bibliográficos
Autores principales: Belcher, Scott M., Burton, Caleb C., Cookman, Clifford J., Kirby, Michelle, Miranda, Gabriel L., Saeed, Fatima O., Wray, Kathleen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585986/
https://www.ncbi.nlm.nih.gov/pubmed/28877739
http://dx.doi.org/10.1186/s40360-017-0160-7

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