Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour

Three novel glass compositions, identified as NCL2 (SiO(2)-based), NCL4 (B(2)O(3)-based) and NCL7 (SiO(2)-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properti...

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Detalles Bibliográficos
Autores principales: Mancuso, Elena, Bretcanu, Oana, Marshall, Martyn, Dalgarno, Kenneth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586035/
https://www.ncbi.nlm.nih.gov/pubmed/29042712
http://dx.doi.org/10.1016/j.ceramint.2017.06.146
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author Mancuso, Elena
Bretcanu, Oana
Marshall, Martyn
Dalgarno, Kenneth W.
author_facet Mancuso, Elena
Bretcanu, Oana
Marshall, Martyn
Dalgarno, Kenneth W.
author_sort Mancuso, Elena
collection PubMed
description Three novel glass compositions, identified as NCL2 (SiO(2)-based), NCL4 (B(2)O(3)-based) and NCL7 (SiO(2)-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
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spelling pubmed-55860352017-10-15 Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour Mancuso, Elena Bretcanu, Oana Marshall, Martyn Dalgarno, Kenneth W. Ceram Int Article Three novel glass compositions, identified as NCL2 (SiO(2)-based), NCL4 (B(2)O(3)-based) and NCL7 (SiO(2)-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process. Elsevier 2017-10-15 /pmc/articles/PMC5586035/ /pubmed/29042712 http://dx.doi.org/10.1016/j.ceramint.2017.06.146 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mancuso, Elena
Bretcanu, Oana
Marshall, Martyn
Dalgarno, Kenneth W.
Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
title Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
title_full Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
title_fullStr Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
title_full_unstemmed Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
title_short Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
title_sort sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586035/
https://www.ncbi.nlm.nih.gov/pubmed/29042712
http://dx.doi.org/10.1016/j.ceramint.2017.06.146
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