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A Soluble Fluorescent Binding Assay Reveals PIP(2) Antagonism of TREK-1 Channels
Lipid regulation of ion channels by low-abundance signaling lipids phosphatidylinositol 4,5-bisphosphate (PIP(2)) and phosphatidic acid (PA) has emerged as a central cellular mechanism for controlling ion channels and the excitability of nerves. A lack of robust assays suitable for facile detection...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586213/ https://www.ncbi.nlm.nih.gov/pubmed/28793254 http://dx.doi.org/10.1016/j.celrep.2017.07.034 |