A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis

[Image: see text] A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. Th...

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Autores principales: Liang, Shengzong, Ebule, Rene, Hammond, Gerald B., Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586251/
https://www.ncbi.nlm.nih.gov/pubmed/28809497
http://dx.doi.org/10.1021/acs.orglett.7b02101
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author Liang, Shengzong
Ebule, Rene
Hammond, Gerald B.
Xu, Bo
author_facet Liang, Shengzong
Ebule, Rene
Hammond, Gerald B.
Xu, Bo
author_sort Liang, Shengzong
collection PubMed
description [Image: see text] A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air.
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spelling pubmed-55862512018-08-15 A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis Liang, Shengzong Ebule, Rene Hammond, Gerald B. Xu, Bo Org Lett [Image: see text] A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air. American Chemical Society 2017-08-15 2017-09-01 /pmc/articles/PMC5586251/ /pubmed/28809497 http://dx.doi.org/10.1021/acs.orglett.7b02101 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Liang, Shengzong
Ebule, Rene
Hammond, Gerald B.
Xu, Bo
A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis
title A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis
title_full A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis
title_fullStr A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis
title_full_unstemmed A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis
title_short A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis
title_sort chlorinating reagent yields vinyl chlorides with high regioselectivity under heterogeneous gold catalysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586251/
https://www.ncbi.nlm.nih.gov/pubmed/28809497
http://dx.doi.org/10.1021/acs.orglett.7b02101
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