Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion

BACKGROUND: Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone d...

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Detalles Bibliográficos
Autores principales: Moore, Joseph B., Zhao, John, Fischer, Annalara G., Keith, Matthew C.L., Hagan, David, Wysoczynski, Marcin, Bolli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586316/
https://www.ncbi.nlm.nih.gov/pubmed/28679560
http://dx.doi.org/10.1161/JAHA.117.006183

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