Cargando…
t‐Darpp is an elongated monomer that binds calcium and is phosphorylated by cyclin‐dependent kinases 1 and 5
t‐Darpp (truncated isoform of dopamine‐ and cAMP‐regulated phosphoprotein) is a protein encoded by the PPP1R1B gene and is expressed in breast, colon, esophageal, gastric, and prostate cancers, as well as in normal adult brain striatal cells. Overexpression of t‐Darpp in cultured cells leads to incr...
Autores principales: | Momand, Jamil, Magdziarz, Patrycja, Feng, You, Jiang, Dianlu, Parga, Elizabeth, Celis, Arianna, Denny, Erin, Wang, Xiaoying, Phillips, Martin L., Monterroso, Estuardo, Kane, Susan E., Zhou, Feimeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586343/ https://www.ncbi.nlm.nih.gov/pubmed/28904862 http://dx.doi.org/10.1002/2211-5463.12269 |
Ejemplares similares
-
Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue
por: Christenson, Jessica L, et al.
Publicado: (2014) -
t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib
por: Christenson, Jessica L., et al.
Publicado: (2015) -
Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance
por: Gu, Long, et al.
Publicado: (2009) -
t-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer Cells
por: Denny, Erin C., et al.
Publicado: (2015) -
Transient Calcium and Dopamine Increase PKA Activity and DARPP-32 Phosphorylation
por: Lindskog, Maria, et al.
Publicado: (2006)