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Contrasting Determinants of Mutation Rates in Germline and Soma

Recent studies of somatic and germline mutations have led to the identification of a number of factors that influence point mutation rates, including CpG methylation, expression levels, replication timing, and GC content. Intriguingly, some of the effects appear to differ between soma and germline:...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Qi, Hongjian, Shen, Yufeng, Pickrell, Joseph, Przeworski, Molly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586376/
https://www.ncbi.nlm.nih.gov/pubmed/28733365
http://dx.doi.org/10.1534/genetics.117.1114