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Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions

Mutagenesis is a widely used method for identifying protein positions that are important for function or ligand binding. Advances in high-throughput DNA sequencing and mutagenesis techniques have enabled measurement of the effects of nearly all possible amino acid substitutions in many proteins. The...

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Detalles Bibliográficos
Autores principales:	Gray, Vanessa E., Hause, Ronald J., Fowler, Douglas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2017
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586385/ https://www.ncbi.nlm.nih.gov/pubmed/28751422 http://dx.doi.org/10.1534/genetics.117.300064

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