Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function

BACKGROUND: Fetal growth impacts cardiovascular health throughout postnatal life in humans. Various animal models of intrauterine growth restriction exhibit reduced heart size at birth, which negatively influences cardiac function in adulthood. The mechanistic target of rapamycin complex 1 (mTORC1)...

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Detalles Bibliográficos
Autores principales: Hennig, Maria, Fiedler, Saskia, Jux, Christian, Thierfelder, Ludwig, Drenckhahn, Jörg‐Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586418/
https://www.ncbi.nlm.nih.gov/pubmed/28778941
http://dx.doi.org/10.1161/JAHA.117.005506

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