ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

BACKGROUND: GPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies. GPVI‐Fc is a potent inhibitor of atherosclerotic plaque‐induce...

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Detalles Bibliográficos
Autores principales: Degen, Heidrun, Borst, Oliver, Ziegler, Melanie, Mojica Munoz, Ann‐Katrin, Jamasbi, Janina, Walker, Britta, Göbel, Silvia, Fassbender, Julia, Adler, Kristin, Brandl, Richard, Münch, Götz, Lorenz, Reinhard, Siess, Wolfgang, Gawaz, Meinrad, Ungerer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586441/
https://www.ncbi.nlm.nih.gov/pubmed/28751543
http://dx.doi.org/10.1161/JAHA.117.005991

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