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The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study
BACKGROUND: Prior studies have demonstrated a link between the metabolic syndrome and increased risk of cardiovascular mortality. Whether the metabolic syndrome is associated with sudden cardiac death is uncertain. METHODS AND RESULTS: We characterized the relationship between sudden cardiac death a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586451/ https://www.ncbi.nlm.nih.gov/pubmed/28835363 http://dx.doi.org/10.1161/JAHA.117.006103 |
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author | Hess, Paul L. Al‐Khalidi, Hussein R. Friedman, Daniel J. Mulder, Hillary Kucharska‐Newton, Anna Rosamond, Wayne R. Lopes, Renato D. Gersh, Bernard J. Mark, Daniel B. Curtis, Lesley H. Post, Wendy S. Prineas, Ronald J. Sotoodehnia, Nona Al‐Khatib, Sana M. |
author_facet | Hess, Paul L. Al‐Khalidi, Hussein R. Friedman, Daniel J. Mulder, Hillary Kucharska‐Newton, Anna Rosamond, Wayne R. Lopes, Renato D. Gersh, Bernard J. Mark, Daniel B. Curtis, Lesley H. Post, Wendy S. Prineas, Ronald J. Sotoodehnia, Nona Al‐Khatib, Sana M. |
author_sort | Hess, Paul L. |
collection | PubMed |
description | BACKGROUND: Prior studies have demonstrated a link between the metabolic syndrome and increased risk of cardiovascular mortality. Whether the metabolic syndrome is associated with sudden cardiac death is uncertain. METHODS AND RESULTS: We characterized the relationship between sudden cardiac death and metabolic syndrome status among participants of the ARIC (Atherosclerosis Risk in Communities) Study (1987–2012) free of prevalent coronary heart disease or heart failure. Among 13 168 participants, 357 (2.7%) sudden cardiac deaths occurred during a median follow‐up of 23.6 years. Participants with the metabolic syndrome (n=4444) had a higher cumulative incidence of sudden cardiac death than those without it (n=8724) (4.1% versus 2.3%, P<0.001). After adjustment for participant demographics and clinical factors other than components of the metabolic syndrome, the metabolic syndrome was independently associated with sudden cardiac death (hazard ratio, 1.70, 95% confidence interval, 1.37–2.12, P<0.001). This relationship was not modified by sex (interaction P=0.10) or race (interaction P=0.62) and was mediated by the metabolic syndrome criteria components. The risk of sudden cardiac death varied according to the number of metabolic syndrome components (hazard ratio 1.31 per additional component of the metabolic syndrome, 95% confidence interval, 1.19–1.44, P<0.001). Of the 5 components, elevated blood pressure, impaired fasting glucose, and low high‐density lipoprotein were independently associated with sudden cardiac death. CONCLUSIONS: We observed that the metabolic syndrome was associated with a significantly increased risk of sudden cardiac death irrespective of sex or race. The risk of sudden cardiac death was proportional to the number of metabolic syndrome components. |
format | Online Article Text |
id | pubmed-5586451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55864512017-09-11 The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study Hess, Paul L. Al‐Khalidi, Hussein R. Friedman, Daniel J. Mulder, Hillary Kucharska‐Newton, Anna Rosamond, Wayne R. Lopes, Renato D. Gersh, Bernard J. Mark, Daniel B. Curtis, Lesley H. Post, Wendy S. Prineas, Ronald J. Sotoodehnia, Nona Al‐Khatib, Sana M. J Am Heart Assoc Original Research BACKGROUND: Prior studies have demonstrated a link between the metabolic syndrome and increased risk of cardiovascular mortality. Whether the metabolic syndrome is associated with sudden cardiac death is uncertain. METHODS AND RESULTS: We characterized the relationship between sudden cardiac death and metabolic syndrome status among participants of the ARIC (Atherosclerosis Risk in Communities) Study (1987–2012) free of prevalent coronary heart disease or heart failure. Among 13 168 participants, 357 (2.7%) sudden cardiac deaths occurred during a median follow‐up of 23.6 years. Participants with the metabolic syndrome (n=4444) had a higher cumulative incidence of sudden cardiac death than those without it (n=8724) (4.1% versus 2.3%, P<0.001). After adjustment for participant demographics and clinical factors other than components of the metabolic syndrome, the metabolic syndrome was independently associated with sudden cardiac death (hazard ratio, 1.70, 95% confidence interval, 1.37–2.12, P<0.001). This relationship was not modified by sex (interaction P=0.10) or race (interaction P=0.62) and was mediated by the metabolic syndrome criteria components. The risk of sudden cardiac death varied according to the number of metabolic syndrome components (hazard ratio 1.31 per additional component of the metabolic syndrome, 95% confidence interval, 1.19–1.44, P<0.001). Of the 5 components, elevated blood pressure, impaired fasting glucose, and low high‐density lipoprotein were independently associated with sudden cardiac death. CONCLUSIONS: We observed that the metabolic syndrome was associated with a significantly increased risk of sudden cardiac death irrespective of sex or race. The risk of sudden cardiac death was proportional to the number of metabolic syndrome components. John Wiley and Sons Inc. 2017-08-23 /pmc/articles/PMC5586451/ /pubmed/28835363 http://dx.doi.org/10.1161/JAHA.117.006103 Text en © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Hess, Paul L. Al‐Khalidi, Hussein R. Friedman, Daniel J. Mulder, Hillary Kucharska‐Newton, Anna Rosamond, Wayne R. Lopes, Renato D. Gersh, Bernard J. Mark, Daniel B. Curtis, Lesley H. Post, Wendy S. Prineas, Ronald J. Sotoodehnia, Nona Al‐Khatib, Sana M. The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study |
title | The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study |
title_full | The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study |
title_fullStr | The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study |
title_full_unstemmed | The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study |
title_short | The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study |
title_sort | metabolic syndrome and risk of sudden cardiac death: the atherosclerosis risk in communities study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586451/ https://www.ncbi.nlm.nih.gov/pubmed/28835363 http://dx.doi.org/10.1161/JAHA.117.006103 |
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