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Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases

OBJECTIVE: The aim of this study was to evaluate the high-resolution computed tomography (HRCT) findings in patients diagnosed with metastatic pulmonary calcification (MPC). MATERIALS AND METHODS: We retrospectively reviewed the HRCT findings from 23 cases of MPC [14 men, 9 women; mean age, 54.3 (ra...

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Autores principales: Belém, Luciana Camara, Souza, Carolina A., Souza Jr., Arthur Soares, Escuissato, Dante Luiz, Hochhegger, Bruno, Nobre, Luiz Felipe, Rodrigues, Rosana Souza, Gomes, Antônio Carlos Portugal, Silva, Claudio S., Guimarães, Marcos Duarte, Zanetti, Gláucia, Marchiori, Edson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586513/
https://www.ncbi.nlm.nih.gov/pubmed/28894330
http://dx.doi.org/10.1590/0100-3984.2016-0123
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author Belém, Luciana Camara
Souza, Carolina A.
Souza Jr., Arthur Soares
Escuissato, Dante Luiz
Hochhegger, Bruno
Nobre, Luiz Felipe
Rodrigues, Rosana Souza
Gomes, Antônio Carlos Portugal
Silva, Claudio S.
Guimarães, Marcos Duarte
Zanetti, Gláucia
Marchiori, Edson
author_facet Belém, Luciana Camara
Souza, Carolina A.
Souza Jr., Arthur Soares
Escuissato, Dante Luiz
Hochhegger, Bruno
Nobre, Luiz Felipe
Rodrigues, Rosana Souza
Gomes, Antônio Carlos Portugal
Silva, Claudio S.
Guimarães, Marcos Duarte
Zanetti, Gláucia
Marchiori, Edson
author_sort Belém, Luciana Camara
collection PubMed
description OBJECTIVE: The aim of this study was to evaluate the high-resolution computed tomography (HRCT) findings in patients diagnosed with metastatic pulmonary calcification (MPC). MATERIALS AND METHODS: We retrospectively reviewed the HRCT findings from 23 cases of MPC [14 men, 9 women; mean age, 54.3 (range, 26-89) years]. The patients were examined between 2000 and 2014 in nine tertiary hospitals in Brazil, Chile, and Canada. Diagnoses were established by histopathologic study in 18 patients and clinical-radiological correlation in 5 patients. Two chest radiologists analyzed the images and reached decisions by consensus. RESULTS: The predominant HRCT findings were centrilobular ground-glass nodules (n = 14; 60.9%), consolidation with high attenuation (n = 10; 43.5%), small dense nodules (n = 9; 39.1%), peripheral reticular opacities associated with small calcified nodules (n = 5; 21.7%), and ground-glass opacities without centrilobular ground-glass nodular opacity (n = 5; 21.7%). Vascular calcification within the chest wall was found in four cases and pleural effusion was observed in five cases. The abnormalities were bilateral in 21 cases. CONCLUSION: MPC manifested with three main patterns on HRCT, most commonly centrilobular ground-glass nodules, often containing calcifications, followed by dense consolidation and small solid nodules, most of which were calcified. We also described another pattern of peripheral reticular opacities associated with small calcified nodules. These findings should suggest the diagnosis of MPC in the setting of hypercalcemia.
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spelling pubmed-55865132017-09-11 Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases Belém, Luciana Camara Souza, Carolina A. Souza Jr., Arthur Soares Escuissato, Dante Luiz Hochhegger, Bruno Nobre, Luiz Felipe Rodrigues, Rosana Souza Gomes, Antônio Carlos Portugal Silva, Claudio S. Guimarães, Marcos Duarte Zanetti, Gláucia Marchiori, Edson Radiol Bras Original Articles OBJECTIVE: The aim of this study was to evaluate the high-resolution computed tomography (HRCT) findings in patients diagnosed with metastatic pulmonary calcification (MPC). MATERIALS AND METHODS: We retrospectively reviewed the HRCT findings from 23 cases of MPC [14 men, 9 women; mean age, 54.3 (range, 26-89) years]. The patients were examined between 2000 and 2014 in nine tertiary hospitals in Brazil, Chile, and Canada. Diagnoses were established by histopathologic study in 18 patients and clinical-radiological correlation in 5 patients. Two chest radiologists analyzed the images and reached decisions by consensus. RESULTS: The predominant HRCT findings were centrilobular ground-glass nodules (n = 14; 60.9%), consolidation with high attenuation (n = 10; 43.5%), small dense nodules (n = 9; 39.1%), peripheral reticular opacities associated with small calcified nodules (n = 5; 21.7%), and ground-glass opacities without centrilobular ground-glass nodular opacity (n = 5; 21.7%). Vascular calcification within the chest wall was found in four cases and pleural effusion was observed in five cases. The abnormalities were bilateral in 21 cases. CONCLUSION: MPC manifested with three main patterns on HRCT, most commonly centrilobular ground-glass nodules, often containing calcifications, followed by dense consolidation and small solid nodules, most of which were calcified. We also described another pattern of peripheral reticular opacities associated with small calcified nodules. These findings should suggest the diagnosis of MPC in the setting of hypercalcemia. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2017 /pmc/articles/PMC5586513/ /pubmed/28894330 http://dx.doi.org/10.1590/0100-3984.2016-0123 Text en © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Belém, Luciana Camara
Souza, Carolina A.
Souza Jr., Arthur Soares
Escuissato, Dante Luiz
Hochhegger, Bruno
Nobre, Luiz Felipe
Rodrigues, Rosana Souza
Gomes, Antônio Carlos Portugal
Silva, Claudio S.
Guimarães, Marcos Duarte
Zanetti, Gláucia
Marchiori, Edson
Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
title Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
title_full Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
title_fullStr Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
title_full_unstemmed Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
title_short Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
title_sort metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586513/
https://www.ncbi.nlm.nih.gov/pubmed/28894330
http://dx.doi.org/10.1590/0100-3984.2016-0123
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