Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()

Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM....

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Autores principales: Kirmse, Brian, Cabrerra-Luque, Juan, Ayyub, Omar, Cusmano, Kristina, Chapman, Kimberly, Summar, Marshall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586549/
https://www.ncbi.nlm.nih.gov/pubmed/28920014
http://dx.doi.org/10.1016/j.ymgmr.2017.04.001
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author Kirmse, Brian
Cabrerra-Luque, Juan
Ayyub, Omar
Cusmano, Kristina
Chapman, Kimberly
Summar, Marshall
author_facet Kirmse, Brian
Cabrerra-Luque, Juan
Ayyub, Omar
Cusmano, Kristina
Chapman, Kimberly
Summar, Marshall
author_sort Kirmse, Brian
collection PubMed
description Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM. FGF21 levels were higher in patients with IEM compared to without IEM (370 pg/dL vs. 0–65 pg/dL). Further study of FGF21 as a biomarker in IEM is warranted.
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spelling pubmed-55865492017-09-15 Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism() Kirmse, Brian Cabrerra-Luque, Juan Ayyub, Omar Cusmano, Kristina Chapman, Kimberly Summar, Marshall Mol Genet Metab Rep Short Communication Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM. FGF21 levels were higher in patients with IEM compared to without IEM (370 pg/dL vs. 0–65 pg/dL). Further study of FGF21 as a biomarker in IEM is warranted. Elsevier 2017-09-04 /pmc/articles/PMC5586549/ /pubmed/28920014 http://dx.doi.org/10.1016/j.ymgmr.2017.04.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Kirmse, Brian
Cabrerra-Luque, Juan
Ayyub, Omar
Cusmano, Kristina
Chapman, Kimberly
Summar, Marshall
Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
title Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
title_full Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
title_fullStr Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
title_full_unstemmed Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
title_short Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
title_sort plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism()
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586549/
https://www.ncbi.nlm.nih.gov/pubmed/28920014
http://dx.doi.org/10.1016/j.ymgmr.2017.04.001
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